The Infectivity and Pathogenicity of a Group 2 Bovine Coronavirus in Pups

Journal of Veterinary Medical Science

Michiko MURATA²  Tsutomu HOHDATSU²  Takashi KANESHIMA²  Hiroyuki KOYAMA²  Sakiko HOSOYA²  Tomomi TAKANO²  Maki TANABE²  Hiroshi TSUNEMITSU¹  Yui NOJIRI²  Ryoko HAGINO² 

[1] Viral Diseases Research Team, National Institute of Animal Health;Department of Veterinary Infectious Disease, School of Veterinary Medicine and Animal Science, Kitasato University

关键词: BCoV;    Coronavirus;    CRCoV;   

DOI  :  10.1292/jvms.69.301

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(4)Canine respiratory coronavirus (CRCoV), which is more closely related to the bovine coronavirus (BCoV), has recently been detected in dogs. In this study, we examined whether BCoV was capable of infecting and exhibiting pathogenicity in dogs. Three 1-month-old pups were oronasally given field isolates of BCoV, and were kept together with 2 control animals. As a result, increases in BCoV-neutralizing antibody titers were confirmed in all pups in the challenged and control groups. Moreover, the virus gene was also detected in oral and rectal swabs by RT-PCR. These results indicate that BCoV infects dogs, and easily infects other dogs that are kept together. However, no clinical symptoms such as respiratory symptoms and diarrhea were observed.

【 授权许可】

Unknown