Octreotide and Bromocriptine Suppress Thyroid Hormone Levels and Thyroid Nodule in an Acromegalic Patient with Nontoxic Autonomous Goiter

Endocrine Journal

MOTOHARU KONDO¹  TOSHIHIDE YOSHIDA¹  TUNEKAZU UMEKAWA¹  AKIRA SHIMATSU²  NAOKI SAKANE¹ 

[1] First Department of Internal Medicine, Kyoto Prefectural University of Medicine;Department of Laboratory Medicine Kyoto University Graduate School of Medicine

关键词: Acromegaly;    Autonomous goiter;    Octreotide;    Bromocriptine;    Thyroid function;   

DOI  :  10.1507/endocrj.44.305

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(31)Cited-By(1)An acromegalic patient with nontoxic autonomous goiter was sequentially treated with octreotide and bromocriptine. Before therapy, serum GH, PRL and insulin-like growth factor-I (IGF-I) levels were increased. Free T3 and free T4 were within the normal range with suppressed TSH levels, whereas 123Iodine-uptake of thyroid was 5.6% after 24h. During treatment with octreotide and bromocriptine, serum GH, PRL, and IGF-I became normal and free T3 and free T4 were slightly but significantly decreased, but TSH levels remained very low. After thyroidectomy, thyroglobulin, free T3 and free T4 were further decreased, and the TSH levels were recovered to normal. These findings suggested that octreotide and bromocriptine inhibit the release of thyroid hormones from the autonomous thyroid gland directly or indirectly through the decline in IGF-I.

【 授权许可】

Unknown