Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients

Endocrine Journal

Eijun Nishihara²  Mitsuru Ito²  Toshiaki Hanafusa¹  Sumihisa Kubota²  Nobuyuki Amino²  Akira Kitanaka³  Tetsuya Hiraiwa¹  Takeshi Arishima²  Akira Miyauchi²  Takumi Kudo² 

[1] First Department of Medicine, Osaka Medical College, Takatsuki 569-8686, Japan;Kuma Hospital, Kobe 650-0011, Japan;Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun 761-0793, Japan

关键词: Apolipoprotein B-48;    Chylomicron remnant;    Hypothyroidism;    L-thyroxine;    Lipoprotein;   

DOI  :  10.1507/endocrj.EJ12-0226

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(37)Cited-By(3)Apolipoprotein B-48 (ApoB-48) is a constituent of chylomicrons and chylomicron remnants, and is thought to be one of the risk factors for atherosclerosis.We evaluated the effect of L-thyroxine (L-T4) replacement on serum ApoB-48 levels in patients with primary hypothyroidism.Eighteen patients with overt hypothyroidism (OH) and 18 patients with subclinical hypothyroidism (SH) participated in the study.The lipid profiles, including ApoB-48, were measured in patients with hypothyroidism before and 3 months after L-T4 replacement.After L-T4 replacement, the serum concentrations of all lipoproteins, exclusive of lipoprotein(a) (Lp(a)), were significantly decreased in patients with OH.In patents with SH, the serum levels of total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), remnant-like particle cholesterol (RLP-C), apolipoprotein B (ApoB), and ApoB-48 decreased significantly after L-T4 replacement.The serum levels of triglycerides (TG), HDL-C, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA-1), and Lp(a) did not change significantly.In all 36 patients, the reduction in the ApoB-48 levels correlated significantly with the reduction in TSH levels (r = 0.39, P4 replacement might reduce serum levels of ApoB-48 in both OH and SH patients.Such altered serum levels of ApoB-48 in patients with OH and SH may be related to the disturbed metabolism of chylomicron remnants in patients with hypothyroidism.

【 授权许可】

Unknown