Abnormal Distribution of Anionic Sites in the Glomerular Basement Membrane in Glomerulonephritis of Dogs Infected with Dirofilaria immitis

Journal of Veterinary Medical Science

Hitoshi KITAGAWA³  Hong-Kean OOI⁴  Munetaka YAMAKI¹  Junichi KAMIIE¹  Kinji SHIROTA¹  Masahiko WASAKI² 

[1] Laboratory of Veterinary Pathology,Azabu University,1-17-71 Fuchinobe,Sagamihara,Kanagawa 229-8501,Japan;Mitsubishi Tokyo Pharmaceutial Co.,Ltd,1000 Kamoshida,Midori-ku,Yokohama 227-0033,Japan;Laboratory of Internal Medicine,Division of Veterinary Medicine,Faculty of Agriculture,Gifu University,Yanagido 1-1,Gifu 501-1193,Japan;Department of Veterinary Medicine,National Chung Hsing University,250 Kuo Kuang Road,Taichung 40227,Taiwan

关键词: anionic site;    canine dirofilariasis;    glomerulonephritis;   

DOI  :  10.1292/jvms.62.1193

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)Cited-By(1)Ultrastructural alteration of anionic sites(ASs)in the glomerular basement membrane(GBM)was studied in glomerulonephritis characterized by linear capillary IgG deposition in four dogs infected with Dirofilaria immitis and two normal control dogs using polyethyleneimine.ASs were identified as small dense particles distributed regularly in the lamina rara externa(LRE), but there were no ASs in the lamina densa(LD)of the GBM of the control dogs.In the glomeruli of the infected dogs, ASs were distributed regularly or irregularly in the thickened LD.ASs were in addition localized over the characteristic continuous bands of subendothelial dense deposits.The number of ASs of the LRE increased in all four infected cases as compared to the controls(p<0.01).

【 授权许可】

Unknown