Microbial activity and toxicity of Euphorbia tirucalli L. (aveloz) latex

Revista Cubana de Plantas Medicinales

Stuelp Campelo, Patrícia Maria²  Ribeiro Rosa, Edvaldo Antonio¹  Cordeiro Arruda, Maria Fernanda²  Takaki Rosa, Rosimeire¹ 

[1] Laboratório de Pesquisa em Xenobióticos;Laboratório de Bioquímica

关键词: cytotoxicity;    medicinal plant;    oral toxicity;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction: Euphorbia tirucalli L. (Euphorbiaceae) latex, commonly used in healing and prevention of various diseases, was evaluated in this study.Objective: to evaluate the antimicrobial activity and toxicity of aveloz latex.Methods: were performed carbohydrates and proteins dosages and analysis of secondary metabolites; antimicrobial activity assays; cytotoxicity in tumor cells and oral toxicity.Results: The latex had 165.29 µg/mL of protein and 129.5 µg/mL of carbohydrate. Alkaloids, coumarins and steroidal nucleus were found. No antimicrobial, hepato or nephrotoxic action were observed and there was no change in the number of blood cells of treated animals. However, it was found 60 % reduction in the adhesion of tumor cells (HeLa) in vitro.Conclusion: The results show that E. tirucalli latex in tested concentrations has low toxicity and has no antimicrobial activity.

【 授权许可】

CC BY-NC