Therapeutic Effect of Frequent Injections of GnRH Analogue in a Beagle with Knobbed Acrosome Abnormality of Sperm

Journal of Veterinary Medical Science

Tatsuya HORI¹  Tomoko YAGI¹  Masanori KOBAYASHI¹  Eiichi KAWAKAMI¹ 

[1] Laboratory of Reproduction, Nippon Veterinary and Life Science University

关键词: canine;    GnRH analogue;    knobbed acrosomal defect;    sperm;   

DOI  :  10.1292/jvms.11-0272

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)Cited-By(2)A Beagle dog (3 years old) that ejaculated high percentages (mean ± SE: 29.1 ± 1.2%) of sperm with a knobbed acrosome abnormality and a low number of sperm and that also had a low plasma testosterone (T) level was given 10 subcutaneous injections of 1 μg of gonadotropin-releasing hormone analogue (GnRH-A) at 3-day intervals. The plasma T level and number of sperm increased 12-14 weeks after the first injection. Although the percentages of sperm with knobbed acrosome abnormality did not change after the GnRH-A therapy, the number of sperm and percentage of actively motile sperm increased after the therapy, and a bitch gave birth to 5 healthy puppies after intravaginal artificial insemination with fresh semen collected 14 weeks after the first injection.

【 授权许可】

Unknown