Drosophila melanogasterゲノムにおける全タンパク質の電荷分布の正規分布解析

Chem-Bio Informatics Journal

�? 閏聡¹  美宅 成樹¹ 

[1] 名古屋大学大学院�?工学研究科�??応用物理学専攻

关键词: proteome;    プロテオーム;    harge distribution;    電荷分布;    Gaussian distribution;    正規分布;    bioinformatics;    バイオインフォマティクス;   

DOI  :  10.1273/cbij.4.101

学科分类：生物化学/生物物理

来源: Chem-Bio Informatics Society

【 摘 要 】

References(8)Cited-By(1)The distribution of net electric charge of amino acid sequences from Drosophila melanogaster is compared with a Gaussian distribution to investigate the balance between randomness and selection in the process of evolution. The net electric charge follows a Gaussian-like distribution, with a slight but systematic deviation from the Gaussian distribution. This deviation is not observed for eleven subsets of proteins of similar size, and it is shown that the mean and variance of the Gaussian distribution appear to be linearly dependent on the size of proteins. The Gaussian distribution is centered around a charge density of approximately one positive charge per 100 residues, which in comparison to the real distribution for random sequences, reveals some degree of charge correlation in the proteome of D. melanogaster. These findings suggest the possible involvement of a systematic selection mechanism in the evolution process.

【 授权许可】

Unknown