Acute Vascular and Interstitial Rejection Following Renal Allograft Transplantation in Dogs

Journal of Veterinary Medical Science

Atsuko HAISHIMA¹  Tatsuo SUZUKI²  Yuki KAWAKAMI²  Kaoru INOUE¹  Satoshi MIZUNO²  Toshiaki KAGEYAMA²  Kinji SHIROTA¹  Makoto MUTO² 

[1] Research Institute of Biosciences, Azabu University;Laboratory of Veterinary Surgery II, Azabu University

关键词: kidney;    rejection;    renal transplantation;   

DOI  :  10.1292/jvms.64.1137

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(10)Cited-By(3)Renal allograft transplantation was performed in four beagles. Immunosuppressive treatment using cyclosporine, mizoribin and prednisolone was continued from Day 5 pre- until Day 20 post-transplantation. Between Days 28 and 32 post-transplantation, an abrupt elevation of the serum creatinine values followed by the development of uremia was seen in all recipients. Histopathology of the allografts examined between Days 28 and 37 revealed edema, necrosis, hemorrhage and severe diffuse interstitial cellular infiltration as well as tubulitis. Glomerular changes notably included swelling of the tufts due to hypercellularity, which was consistent with transplant glomerulitis. The intrarenal arteries exhibited fibrinoid necrosis of the walls and intimal or transmural cellular infiltration. These renal lesions were consistent with those of acute vascular and interstitial rejection in humans.

【 授权许可】

Unknown