Steroid Hormones Do Not Reactivate Neospora caninum in Ovariectomized Mice

Journal of Veterinary Medical Science

Takashi KIMURA¹  Kenji OCHIAI¹  Atsushi KOBAYASHI¹  Seiji KATAGIRI²  Takashi UMEMURA¹ 

[1] Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University;Laboratory of Theriogenology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University

关键词: corticosterone;    estradiol-17β;    latent infection;    Neospora caninum;    progesterone;   

DOI  :  10.1292/jvms.64.773

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)Cited-By(2)The direct effects of three steroid hormones (progesterone, estradiol-17β and corticosterone) on the growth of Neospora caninum (N. caninum) tachyzoite were examined in Vero cells. Subsequently, ovariectomized BALB/c mice infected with N. caninum were treated with physiological concentrations of the steroid hormones for 1 or 2 weeks. These hormones had no direct effect on the parasite growth in vitro. In the infected mice, there was no significant difference in the parasite distribution and histopathological changes between the hormone-injected and control groups. No mice showed parasitemia at the time of autopsy. These results suggest that physiological levels of steroid hormones (progesterone, estradiol-17β and corticosterone) do not reactivate N. caninum in mice.

【 授权许可】

Unknown