Toxicological study of an aqueous extract from Enterolobium cyclocarpum (Jacq.) Griseb. duramen

Revista Cubana de Plantas Medicinales

Raya González, David³  Chávez Duran, Judith²  Morales López, María E.²  Castro Ortiz, Ricardo³  Urrutia Hernández, Sara E.³  Martínez Pacheco, Mauro Manuel³  Cajero Juárez, Marco¹ 

[1] Facultad de Medicina Veterinaria-CMEB, Morelia, México;Facultad de Ciencias Médicas y Biológicas Morelia, Morelia, México;Instituto de Investigaciones Químico Biológicas, Morelia, México

关键词: : IC50/LC50;    crustacean;    termite;    rat;    bacteria;    fungus;    oomicet;    MCF-7 cells;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Rationale: A protective effect of the aqueous extract from Enterolobium cyclocarpum (Jacq.) Griseb duramen on pinewood was reported. It was also attributed anti-nutritional and repellent action against dry wood termites Incisitermes marginipennis (Latreillé); it is considered a potential candidate for perishable dry wood preservation, whose possible toxicity must be studied.Objectives: To determine the toxicity of aqueous extract from E. cyclocarpum duramen.Methods: Mean inhibitory and lethal concentrations (IC50/LC50) of an aqueous extract from E. cyclocarpum duramen in organisms from different trophic levels.Results: LC50 for Artemia salina crustacean, I. marginipennis termite and Wistar rat were 1,3; 2 mg/mL and over 2 000 mg/kgind respectively. In microbial isolates, IC50 was 300 mg. In MCF-7 tumor cell line, IC50 was 1,3 mg.Conclusions: When comparing observed IC50/LC50 with allowable toxicity limits, it was concluded that the extract under study was not toxic for these organisms.

【 授权许可】

CC BY-NC