The Accessory Cell Activity of Porcine Intestinal Macrophages in the Induction of T Cell Responses

Journal of Veterinary Medical Science

Chris STOKES¹  Dominic KAMBARAGE¹  Paul BLAND¹ 

关键词: antigen presenting cell;    intestinal macrophage;    MHC class II antigen;    mixed leukocyte response;    oxidative mitogenesis;   

DOI  :  10.1292/jvms.56.1135

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(2)Although intestinal macrophages stimulated significant T cell responses to MHC class II antigens and polyclonalmitogens, they were weak stimulators of ovalbumin-driven responses. These cells showed numerous and large endocytic vacuoles, lysosomes and phagolysosomes which may be indicative of active phagocytosis during the isolation process. The poor antigen presenting activity of the cells in protein antigen-elicited may be an in vitro artifact attributed to acquired inefficiency in antigen uptake and/or processing.

【 授权许可】

Unknown