Long-Term Clinical Course of Two Cases of Lymphocytic Adenohypophysitis

Endocrine Journal

MEGUMU HINO²  HIROMASA KOBAYASHI¹  MARIKO KAJIKAWA¹  HIROYUKI KURAHACHI¹  KUNISABURO MORIDERA¹  TAKASHI ISHIHARA¹  KATSUJI IKEKUBO²  NAOKI HATTORI¹ 

[1] Departments of Endocrinology, Kobe City General Hospital;Departments of Nuclear Medicine, Kobe City General Hospital

关键词: Lymphocytic adenohypophysitis;    Magnetic resonance imaging (MRI);    Hypopituitarism;    Empty sella;    Sheehan's syndrome;   

DOI  :  10.1507/endocrj.43.433

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(22)Cited-By(21)In two patients with lymphocytic adenohypophysitis, images of the pituitary gland were serially observed by MRI. In both cases, the pituitary gland had swollen during the late stage of the first pregnancy. In case 1, MRI findings were representative of lymphocytic adenohypophysitis. After delivery, plasma levels of PRL, ACTH and cortisol decreased markedly. The height of the pituitary gland gradually decreased from 22mm (14 days after delivery) to 13mm (73 days) and became rapidly smaller (4.9mm, 115 days) following administration of massive doses of hydrocortisone for the treatment of acute adrenal insufficiency induced by painless thyroiditis. Six years later, the height was 2.5mm. Low plasma levels of PRL and cortisol persisted. Diabetes insipidus did not develop. In case 2, MRI revealed a pituitary mass accompanied by a cystic change. Lymphocytic adenohypophysitis was confirmed by histological examination. Because pituitary function tests indicated that ACTH, PRL, GH and TSH were of low levels, hydrocortisone and L-thyroxine were orally administered. No diabetes insipidus was demonstrated. MRI disclosed that the height of the pituitary gland was 23mm (17 days after delivery) but decreased to 17 and 5.5mm after 44 and 128 days, respectively. Four years later immediately after the second delivery, it was 1mm, and the patient was diagnosed as having empty sella. Long-term observation of lymphocytic adenohypophysitis demonstrated that the pituitary gland was markedly atrophied, leading to empty sella. It is believed that some of the classic cases of Sheehan's syndrome associated with empty sella may include lymphocytic adenohypophysitis.

【 授权许可】

Unknown