Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells

Journal of Pharmacological Sciences

Takeki Tsutsui¹  Fusae Yamaguchi¹ 

[1] Department of Pharmacology, The Nippon Dental University, School of Dentistry at Tokyo

关键词: morphological transformation;    chemical agents used in dentistry;    Syrian hamster embyo cell;   

DOI  :  10.1254/jphs.93.497

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(12)Fourteen chemical agents used in dental practice were assessed for their cell-transforming activity using the Syrian hamster embryo (SHE) cell transformation assay system. The cell-transforming activity was quantitatively assessed by the frequency of morphological transformation (MT) in SHE cells induced by these agents. MT was induced by m-cresol, guaiacol, formaldehyde, sodium hypochlorite, hydrogen peroxide, sodium arsenite, acid fuchsin, and basic fuchsin, but not by p-chlorophenol, p-phenolsulfonic acid, glutaraldehyde, and erythrosine B. Iodine and chlorhexidine exhibited positive and pseudopositive responses, respectively. The chemical agents exhibiting a negative or pseudopositive response neither induced nor enhanced MT even in the presence of exogenous metabolic activation.

【 授权许可】

Unknown