Erdosteine in Renal Ischemia-Reperfusion Injury: An Experimental Study in Pigs

Journal of Veterinary Medical Science

Chang-Sik PARK³  Hyun-Soo KIM¹  Myung-Cheol KIM²  Jae-Yeon LEE² 

[1] Department of Veterinary Public Health, College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University;Department of Veterinary Surgery, Research Center for Transgenic Cloned Pigs, Chungnam National University;Division of Animal Science & Resources, Research Center for Transgenic Cloned Pigs, Chungnam National University

关键词: antioxidant enzyme;    erdosteine;    ischemia-reperfusion injury;    pigs;   

DOI  :  10.1292/jvms.09-0255

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)Cited-By(3)The aim of the present study was to investigate the effect of erdosteine on renal reperfusion injury. Twelve male Landrace and Yorkshire mixed pigs were randomly divided into two groups: untreated control group (I/R), erdosteine treated group (I/R + erdosteine). Each group is composed of six pigs, and the pigs were unilaterally nephrectomized and their contralateral kidneys were subjected to 30 min of renal pedicle occlusion. The elevations of creatinine and blood urea nitrogen levels were lower in the treated group compared with the control group. The catalase activity and the glutathione peroxidase activity were higher in the erdosteine group. As a result, this study suggests that the erdosteine treatment has a role of attenuation of renal I/R injury recovery of renal function in pig.

【 授权许可】

Unknown