Preclinical validation of the peripheral and central analgesic activity of decoction of fresh leaves of Persea americana Mill. (avocado) and Musa x paradisiaca L. (banana)

Revista Cubana de Plantas Medicinales

Victoria Amador, María del Carmen¹  Morón Rodríguez, Francisco J¹  Brito Alvarez, Gisselle¹  García Hernández, Ana Ibis¹  Martínez Hormaza, Ioanna¹  Boucourt Rodríguez, Elisa¹  López Barreiro, Marisol¹  Doménigo González, Abel¹  Acosta de la Luz, Lérida Lázara¹  Morejón Rodríguez, Zulema¹ 

[1] Universidad de Ciencias Médicas de La Habana Dr. Salvador Allende, La Habana, Cuba

关键词: Persea americana;    avocado;    Musa x paradisiaca;    banana;    analgesia;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction:Persea americanaMill. (avocado) and Musa x paradisiaca L. (banana) are medicinal plants with traditional uses in folk medicine. Reports refer to the beneficial effects of a decoction of fresh leaves of avocado in the treatment of urinary infection, coughing and bronchitis. Decoction of banana fresh leaves is used to treat the flu, coughing and inflammation. This has been documented by TRAMIL surveys. The preclinical information found in the databases SciELO, CUMED, LIS CUBA and MEDLINE was not sufficient to validate the uses listed above. Objectives:evaluate the preclinical peripheral and central analgesic activity of a 30 % decoction of fresh leaves of Persea americana Mill. (avocado) and Musa x paradisiaca L. (banana). Methods: fresh leaves of P. americana and M. paradisiaca were collected and 30 % decoctions were prepared. Peripheral analgesic activity was evaluated with the acetic acid induced writhing model (writhing test), whereas central analgesic activity was assessed with the tail flick model in mice by immersion in 55 oC water. The doses used were 1, 5 and 10 grams of plant material / kg of body weight. Results: decoctions of fresh leaves of P. americana and M. paradisiaca at the study doses significantly inhibited the painful response induced by acetic acid with p=6.909e-08 and p=2.842e-03, respectively. In the tail flick evaluation the decoction of fresh leaves of P. americana had a significant non-dose dependent response at 5g/kg with p=7.018e-03. A significant response was not obtained from the other doses studied or from the M. paradisiaca decoction. Conclusions: results permit the preclinical validation of the peripheral analgesic activity of the decoction of fresh leaves of P. americana (avocado) and M. paradisiaca (banana), as well as the central analgesic activity of P. americana, validating the traditional use of both plants.

【 授权许可】

Unknown