Distant metastasis at diagnosis and large tumor size are significant prognostic factors of widely invasive follicular thyroid carcinoma

Endocrine Journal

Yuuki Takamura¹  Tomonori Yabuta¹  Akihiro Miya¹  Minoru Kihara¹  Mitsuyoshi Hirokawa²  Yasuhiro Ito¹  Hiroo Masuoka¹  Kaoru Kobayashi¹  Mitsuhiro Fukushima¹  Takuya Higashiyama¹  Akira Miyauchi¹ 

[1] Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan;Department of Pathology, Kuma Hospital, Kobe 650-0011, Japan

关键词: Follicular carcinoma;    Widely invasive;    Prognosis;    Distant metastasis;    Tumor size;   

DOI  :  10.1507/endocrj.EJ12-0454

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(27)Cited-By(3)In contrast to minimally invasive follicular thyroid carcinoma (FTC), widely invasive FTC is aggressive and is associated with a dire prognosis.However, prognostic factors of widely invasive FTC have not been intensively investigated.In this study, we investigated this issue in a series of 79 widely invasive FTC patients.In the subset of 70 patients who did not show distant metastasis at diagnosis (M0), only a tumor size larger than 4 cm had a prognostic impact on disease-free survival (DFS) both on uni- and multivariate analyses. Regarding the cause-specific survival (CSS) of 79 patients, only distant metastasis at diagnosis (M1) had a significant prognostic value on uni- and multivariate analyses.None of the 70 M0 patients with a tumor measuring 4 cm or less died of FTC.Other clinicopathological features such as age, gender, and oxyphilic carcinoma were of no prognostic value.These findings suggest that 1) M1 is the strongest prognostic factor for CSS of widely invasive FTC patients, and 2) a tumor size larger than 4 cm significantly affects the DFS and CSS of M0 patients.Aggressive therapies with careful follow-up are recommended, especially for these patients.

【 授权许可】

Unknown