Synthesis and Biological Evaluation of 6-Hydroxy-4-Methyl-5,7-(Bis-p-ChlorophenylAzo) Coumarin | Science Publications

American Journal of Applied Sciences

Juliana Jumal¹  Dalal M. Ibrahim¹  Farah Wahida Harun¹ 

关键词: Bis-Coumarins;    Cytotoxic Activity;    Breast Cancer;   

DOI  :  10.3844/ajassp.2016.1.6

学科分类：自然科学（综合）

来源: Science Publications

【 摘 要 】

6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo)coumarinhas been synthesized  and characterizedby CHN elemental analysis, FTIR, ¹H-NMR-spectroscopy andmass-spectral data. Cytotoxic screening by MTT assay was carried out on the compoundagainst breast cancer cells. The overall results from preliminary screeningprogram revealed that the cell proliferation was highly inhibited by 6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo)coumarin with the value of 2.81%, at concentration of 30 µg mL^-1 comparedwith the untreated control cells and also possessed a good chelating activitywith IC₅₀ value 1.87 µg mL^-1. It issuggested that the cytotoxic activity is affected by hydroxyl and halogengroups as these groups have high electron affinity and high electronegativity.

【 授权许可】

Unknown