An Outbreak of Highly Pathogenic Avian Influenza Subtype H5N1 in Broiler Breeders, Korea

Journal of Veterinary Medical Science

Eun-kyoung LEE¹  Haan-woo SUNG¹  Min-chul KIM¹  Youn-jeong LEE¹  Jun-gu CHOI¹  Sung-Hwan WEE²  Sung-jun JOH¹  Yong-kuk KWON¹  Jae-hong KIM¹ 

[1]Avian Disease Division, National Veterinary Research and Quarantine Service

[2]Veterinary Epidemiology Division, National Veterinary Research and Quarantine Service

关键词: broiler breeder;    highly pathogenic avian influenza;    H5N1;    South Korea;   

DOI  :  10.1292/jvms.67.1193

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(7)Highly pathogenic avian influenza (HPAI) was diagnosed in broiler breeders, submitted to the National Veterinary Research and Quarantine Service in South Korea. Grossly, the dead breeders had lesions consistent with HPAI, including pancreatic mottling, splenomegaly, pulmonary edema and congestion, and hemorrhages in the mucosa of the proventriculus, gizzard and small intestine, and on the serosal surface. Microscopically, there were necrotized hepatitis and pancreatitis, lymphocytic meningoencephalitis, myocarditis, and interstitial pneumonia. Influenza viral antigen was demonstrated in areas closely associated with histopathologic lesions. The AI virus was isolated from cecal tonsils, feces, trachea, and kidney of the chickens. The isolated virus was identified as the highly pathogenic H5N1, with a hemagglutinin proteolytic cleavage site deduced amino acid sequences of QREKRKKR/GLFGAGLFGAIAG. In order to determine the pathogenicity of the isolate, eight 6-week-old specific pathogen free chickens were inoculated intravenously with the virus, and all the birds died within 24 hr after inoculation. This is the first report of an outbreak of HPAI in the chickens in South Korea.

【 授权许可】

Unknown