In vitro Evaluation of Aldoxime Interactions with Human Acetylcholinesterase

Croatica Chemica Acta

Bosak, Anita²  Kovarik, Zrinka²  Jelić, Dubravko¹  Čalić, Maja²  Šinko, Goran² 

[1] GlaxoSmithKline Istraživački Centar, Zagreb, Hrvatska;Institut za medicinska istaživanja i medicinu rada, Zagreb, Hrvatska

关键词: cytotoxicity;    nerve agents;    oxime;    phosphorylation;    protection;    reactivation;   

DOI  :  

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

We related the ability of eleven pyridinium and imidazolium aldoximes to reactivate tabun-inhibited human erythrocyte acetylcholinesterase with their molecular properties. Using molecular mechanics we performed conformational analysis to...

【 授权许可】

Unknown