Evaluation of the acute and subchronic oral toxicity of ethanol extract from Valeriana pavonii species in Wistar rats

Colombia Médica

Mario Francisco Guerrero¹  María Del Pilar Olaya²  María Constanza Lozano²  Lucía Botero²  Javier Rincón² 

[1] Universidad Nacional de Colombia;Universidad Nacional de Colombia

关键词: Toxicity tests;    LOAEL;    Valerian;    NOAEL;    Anxiolytic;    Medicinal plants.;   

DOI  :  

学科分类：医学（综合）

来源: Universidad del Valle * Facultad de Salud / Universidad del Valle, Faculty of Health

【 摘 要 】

Introduction:One of the most frequent problems found in medicinal plants is the absence of clinical, toxicological, and pharmacological studies. Valeriana pavonii is one of the species used in Colombia as an anxiolytic.  Further study of this specie is rendered to add information in the toxicological area. Objective:The acute and subchronicoral toxicity of V. pavonii ethanolic extract was evaluated in Wistarrats of both sexes. Materials and methods:The rats were distributed into four groups: the control group received the vehicle (0.5 mL/100 g of corporal weight) and the other three groups received increasing levels of the dosage for 90 days to evaluate characteristics like physical exam, laboratory test (blood chemistry and  haematology), and anatomopathological findings.Results:This study reveals that there were no signs of toxicity, mortality, or significant alterations attributable to the ethanolic extract of V. pavonii.Conclusions:The Not Observed Adverse Effect Levels (NOAEL) of V. pavonii ethanolic extract were 2000 and 1000 mg/kg of body weight for the acute and subchronic toxicity studies, respectively.

【 授权许可】

Unknown