Effect of road transportation on the serum biochemical parameters ofcynomolgus monkeys and beagle dogs

Journal of Veterinary Medical Science

Noriko NISHINA¹  Azusa YAMADA²  Hironari KOYAMA³  Yuki NAGANUMA³  Takehiro OCHI³ 

[1] Drug Safety Research Labs., Astellas Pharma Inc., 1�?6, Kashima 2-chome, Yodogawa-ku, Osaka 532�?8514, Japan;Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 21, Miyukigaoka, Tsukuba, Ibaraki 305�?8585, Japan;Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1�?6, Kashima 2-chome, Yodogawa-ku, Osaka 532�?8514, Japan

关键词: acclimation period;    blood parameter;    canine;    monkey;    transportation;   

DOI  :  10.1292/jvms.15-0502

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)To determine the effect of long-distance (approximately 600 km) road transportation onthe blood biochemistry of laboratory animals, we investigated the changes in serumbiochemical parameters in healthy cynomolgus monkeys and beagle dogs transported by truckfrom Osaka to Tsukuba, Japan. The concentrations of serum cortisol, total bilirubin andaspartate aminotransferase in monkeys increased during transportation. Serum cortisol andtotal bilirubin levels in dogs also increased during transportation, but serumtriglyceride decreased. Serum parameter values in truck-transported monkeys and dogsreturned to baseline levels within two weeks following arrival. Taken together, theseresults suggest that a two-week acclimation period is the minimum duration required foradaptation following road transportation.

【 授权许可】

Unknown