Protective Effect of Sauchinone on Methamphetamine-Induced Neurotoxicity in Mice

Journal of Pharmacological Sciences

Kyung Ah Park²  Meeyul Hwang¹  Chae Ha Yang²  Eun Young Jang²  Jong Rock Lee¹ 

[1] The Research Center for Biomedical Resource of Oriental Medicine, Daegu Haany University, South Korea;Department of Oriental Medicine, College of Oriental Medicine, Daegu Haany University, South Korea

关键词: methamphetamine;    sauchinone;    nitric oxide;   

DOI  :  10.1254/jphs.11207SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(5)Sauchinone is a lignan isolated from Saururus chinensis known to suppress nitric oxide (NO) activity. Previous studies demonstrate that NO plays a key role in methamphetamine-induced neurotoxicity. Thus, we hypothesized that sauchinone could have a suppressive effect on the neurotoxicity induced by methamphetamine. Repeated injections of methamphetamine cause degeneration of dopaminergic nerve terminals, whereas sauchinone treatment significantly prevented this degeneration. Sauchinone treatment also inhibited the methamphetamine-induced activation of glia cells and the production of NO via a blockade of inducible NO synthase protein expression. Our results suggest that sauchinone can prevent methamphetamine-induced neurotoxicity through the suppression of NO production.

【 授权许可】

Unknown