Association of serum bone morphogenetic protein 4 levels with obesity and metabolic syndrome in non-diabetic individuals

Endocrine Journal

Ki-Ho Song¹  Kun-Ho Yoon¹  Hyun Shik Son¹  Ki-Hyun Baek¹  Mee-Kyoung Kim¹  Bong-Yun Cha¹  Hyuk-Sang Kwon¹  Won Chul Lee²  Jang-Won Son¹  Ho-Young Son¹  Yong-Moon Park²  Soon-Jib Yoo¹ 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea;Department of Preventive Medicine, The Catholic University of Korea, Seoul, Korea

关键词: Bone morphogenetic protein;    Obesity;    Metabolic syndrome;   

DOI  :  10.1507/endocrj.K10E-248

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(27)Cited-By(9)Bone morphogenetic protein 4 (BMP-4) is involved in the earliest stages of adipocyte differentiation and is recognized as an adipogenic factor for white adipose tissue.The association of serum BMP-4 levels with anthropometric and metabolic parameters has not been previously studied.We aimed to explore the relationship of serum BMP-4 levels with obesity and metabolic syndrome.Serum BMP-4 levels were measured in 104 non-diabetic individuals from the Chungju Metabolic Disease Cohort Study.Anthropometric measurements and components of metabolic syndrome were assessed in all patients.Serum BMP-4 levels were significantly increased in individuals with obesity or metabolic syndrome.After adjusting for age and gender, serum BMP-4 levels were positively correlated with body mass index, waist circumference (WC), waist-to-hip ratio, fasting plasma insulin, homeostasis model assessment index, and triglycerides and were negatively correlated with high-density lipoprotein (HDL) cholesterol.Among these parameters, WC and HDL cholesterol were found to be independent contributing factors for serum BMP-4 levels.Serum BMP-4 levels were also significantly higher in subjects with positive diagnostic criteria for each component of metabolic syndrome.The area under the receiver operating characteristic curve for BMP-4 was 0.661 (P = 0.022, 95% CI = 0.528 to 0.794) and the cut-off value was 2.84 pg/mL.This is the first demonstration that serum BMP-4 levels are associated with adiposity, insulin resistance, and the presence of metabolic syndrome.Whether BMP-4 may be involved in the pathogenesis of obesity and metabolic syndrome deserves further investigation.

【 授权许可】

Unknown