Intrapulmonary concentration of enrofloxacin in healthy calves

Journal of Veterinary Medical Science

Shingo ISHIKAWA²  Masaya HIRATA²  Michiko NOGUCHI²  Tomonobu IKEDO²  Chie HORINOUCHI²  Konosuke OTOMARU²  Shun-ichi NAGATA¹  Seiji HOBO² 

[1]Laboratory of Racing Chemistry, 1731�?2 Tsuruta-machi, Utsunomiya, Tochigi 320�?0851, Japan

[2]Joint Faculty of Veterinary Medicine, Kagoshima University, 1�?21�?24 Korimoto, Kagoshima 890�?0065, Japan

关键词: bronchoalveolar lavage fluid;    calf;    distribution;    enrofloxacin;    pulmonary epithelial lining fluid;   

DOI  :  10.1292/jvms.15-0495

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)To determine the intrapulmonary concentration of enrofloxacin (ERFX) in calves, plasma, bronchoalveolar lavage fluid (BALF) and alveolar cells samples were obtained from clinically healthy calves. Four clinically healthy calves were administered a single dose of ERFX (5 mg/kg) by subcutaneous injection. Samples of plasma were obtained for each subjects at 0 (before administration), 1 and 2 hr after administration of ERFX. Samples of BALF were obtained from each subject at 0, 1 and 2 hr after administration of ERFX. This examination was conducted two times, one week apart. The mean EFRX concentrations in plasma at 1 and 2 hr after administration were l.23 and 1.29 µg/ml, respectively. The mean EFRX concentrations in pulmonary epithelial lining fluid (ELF) at 1 and 2 hr after administration 8.53 µg/ml and 9.42 µg/ml, respectively. The mean ERFX concentrations of alveolar cells in BALF at 1 and 2 hr after administration were 4.04 µg/ml and 5.19 µg/ml, respectively. These results suggest that the ERFX concentrations in ELF and alveolar cells concentrations in BALF at 1 and 2 hr after administration were higher than the plasma concentrations.

【 授权许可】

Unknown