Mutation Analysis of RAP1 Gene in Papillary Thyroid Carcinomas

Endocrine Journal

Michiko MATSUSE³  Shunichi YAMASHITA³  Eugeny LUSHNIKOV⁴  Keiji SUZUKI³  Tatiana ROGOUNOVITCH³  Yuka NAKAZAWA³  Norisato MITSUTAKE³  Vladimir SAENKO¹  Pavel RUMYANTSEV² 

[1] Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences;Department of Radiosurgery, Medical Radiological Research Center;Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences;Department of Pathology, Medical Radiological Research Center

关键词: RAP1;    Mutation;    Papillary thyroid cancer;   

DOI  :  10.1507/endocrj.K08E-244

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(13)Cited-By(4)In human papillary thyroid carcinomas (PTCs), the genetic alterations of RET/PTC, RAS or BRAF account for about 60-70% of cases with practically no overlap, providing strong genetic evidence that constitutive active signaling along MAPK pathway is critical for PTC development. In the remaining 30-40% of the cases, the oncogenes are still unknown. RAP1 is a member of the RAS family of small G proteins transmitting signals from the TSH-R to MAPK pathway using cAMP-dependent mechanism in thyroid cells. RAP1 was shown to have both mitogenic and tumorigenic properties in certain systems; however, the potential role of RAP1 mutation in thyroid carcinogenesis has yet to be elucidated. In this study, we analyzed the mutational status of RAP1 gene in 36 Russian patients with PTCs without RET/PTC rearrangement, BRAF mutation or RAS mutation. No mutations in either RAP1A or RAP1B genes were found. These results suggest that RAP1 mutation does not play an important role in PTC pathogenesis.

【 授权许可】

Unknown