Comparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitro | Science Publications

American Journal of Agricultural and Biological Sciences

Aroonsri Priprem¹  Chidchanok Khamlert¹  Padungkwan Chitropas¹  Theera Rittirod¹  Sarayut Radapong¹  Thaned Pongjanyakul¹ 

关键词: Scale region;    shed king cobra skin;    human skin;    permeation;    barrier membrane;   

DOI  :  10.3844/ajabssp.2008.444.450

学科分类：农业科学（综合）

来源: Science Publications

【 摘 要 】

Scales of shed king cobra (Ophiophagus hannah) skin from the dorsal portions, (SSS) and human breast epidermis (HE) were used as barrier membranes for comparison in an in vitro drug permeation study of nine active compounds (MW range 150-300 g mol^-1, pK_a 3-10). Each compound, saturated in a donor solution at pH 4.0 or 5.6, permeated through the barrier membrane, fully hydrated. A receptor solution at pH 7.4 was sampled for quantification at its λ_max by UV-Visible spectrophotometry and/or HPLC. The permeability coefficients of nine compounds were correlated to the n-octanol/water partition coefficients of these compounds. The permeability coefficient of these compounds using HE and SSS was correlated. Scales of shed skin from the dorsal portions of king cobras were shown to be well correlated to the human breast epidermis in this in vitro aqueous permeation study of these compounds.

【 授权许可】

Unknown