Characterization of Equid Herpesvirus 1 (EHV-1) Related Viruses from Captive Grevy's Zebra and Blackbuck

Journal of Veterinary Medical Science

Kerstin BORCHERS²  Hanns LUDWIG²  Frederik WIDÈN³  Dietmar LIECKFELDT²  Daniel BÖTTNER²  Arne LUDWIG²  George ALLEN⁴  Kai FRÖLICH¹  Berndt KLINGEBORN² 

[1] Leibniz-Institute for Zoo and Wildlife Research Berlin;Institut für Virologie, FU Berlin, Königin-Luise-Str;Department of Virology, The National Veterinary Institute, (SVA);Department of Veterinary Science, Gluck Equine Research Center, Universitiy of Kentucky

关键词: antelope;    equid alphaherpesvirus;    zebra;   

DOI  :  10.1292/jvms.68.757

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Cited-By(6)Equid herpes virus 1 (EHV-1) related isolates from a captive blackbuck (strain Ro-1) and Grevy's zebra (strain T965) behaved similarly to EHV-1 and EHV-9 in respect to their host cell range. Restriction enzyme analysis and a phylogenetic tree confirmed that Ro-1 and T965 were identical and more closely related to EHV-1 than to EHV-9. Differences from EHV-1 became obvious firstly, by amino acid alignments revealing two unique substitutions in the gB protein of Ro-1 and T965. Secondly, an EHV-1 type-specific monoclonal antibody did not detect its antigen on Ro-1, T965 or EHV-9 infected cells by immunohistochemistry. The results support the view that Ro-1 and T965 isolates represent a distinct, previously unrecognized species of equid herpesviruses.

【 授权许可】

Unknown