A Study of Reproductive Performance in Pregnant, IL-2 Receptor β-chain Overexpressed Transgenic Mice

Journal of Veterinary Medical Science

Shigeru SAITO³  Orie NAKAMURA⁶  Yasuo KISO⁶  Yasuharu NAMBA⁶  Eiichi HONDO⁶  Eiji SAGARA⁵  Ken KUSAKABE²  Mamoru ITO¹  Masahiro MORIMOTO⁴ 

[1] Department of Immunology, Central Institute for Experimental Animals;Department of Anatomy and Biology, Osaka Medical College;Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University;Veterinary Pathology, Faculty of Agriculture, Yamaguchi University;Animal Research Center, Kyushu Dental College;Departments of Veterinary Anatomy, Yamaguchi University

关键词: IL-2 receptor β-chain overexpression;    placenta;    transgenic mouse;   

DOI  :  10.1292/jvms.63.99

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(9)Relationships between female reproductive performance and uterine natural killer (uNK) cells were investigated in pregnant IL-2 receptor β-chain overexpressed transgenic (Tg2R β) mice. At 8 days of pregnancy, all fetuses were alive, suggesting that implantation normally occurred in these mice. However, 47% of fetuses were dead at 10 days of pregnancy and at 12 days all fetuses were resorbing, indicating that fetal loss progressed with the advance of pregnancy. The placenta of Tg2Rβ mice gradually decreased in weight with the advance of pregnancy. At 10 days the placental labyrinth, decidua basalis, and metrial gland in Tg2Rβ mice were poorly developed, and more uNK cells were found in Tg2Rβ mice than in the control mice. We propose that Tg2Rβ mice are the first and interesting model that uNK cells can cause abortion, to clarify the involvement of uNK cell function in female reproductive performance.

【 授权许可】

Unknown