A Study of Metabolites Isolated from the Urine Samples of Cats and Dogs Administered Orbifloxacin

Journal of Veterinary Medical Science

Hiromi KATAE¹  Shuji MATSUMOTO¹  Noriyuki KITADAI¹  Mikio TAKAHASHI² 

[1] Research Laboratories, Animal Science Division, Dainippon Pharmaceutical Co., Ltd.;Marupi Lifetech Co., Ltd.

关键词: canine;    feline;    orbifloxacin metabolite;   

DOI  :  10.1292/jvms.60.1259

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(6)Cited-By(9)Urine samples of cats and dogs collected for 24 hr after a subcutaneous injection of orbifloxacin (OBFX) were analyzed. The metabolites were examined using HPLC. In the dog urine, 87% of total was the parent compound and 13% glucuronide compound of OBFX and 96% was parent and 4% metabolite in the cat urine. The metabolite of cat urine was identified as N-hydroxy OBFX, determined by comparison of the extraction of urine with chloroform with the standard compound of N-hydroxy OBFX, using LC/APCIMS. N-hydroxy OBFX had a weaker antibacterial activity against fluoroquinolone sensitive bacteria than the parent compound.

【 授权许可】

Unknown