Papillary thyroid carcinoma involving cervical neck lymph nodes: correlations with lymphangiogenesis and ultrasound features

Endocrine Journal

Jisup Yun⁴  Dong-Hoon Kim¹  Mison Chun⁶  Kyung Joo Park³  Yoonjung Choi⁵  Doo Kyoung Kang³  Seungho Ryu² 

[1]Department of Pathology, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine, Seoul, Korea

[2]Medical Screening Center/Department of Occupational Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine, Seoul, Korea

[3]Department of Radiology, Ajou University School of Medicine, Suwon, Korea

[4]Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

[5]Department of Radiology, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine, Seoul, Korea

[6]Department of Radioation Oncology, Ajou University School of Medicine, Suwon, Korea

关键词: Lymphangiogenesis;    Papillary thyroid cancer;    Ultrasonography;    Pathology-thyroid;    Thyroid cancer;   

DOI  :  10.1507/endocrj.EJ12-0178

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(5)Stratification of risk factors for cervical lymph node metastasis (LNM) in thyroid papillary carcinoma is important for providing standards for post-operative adjuvant radio-iodine therapy and for patient prognosis.We investigated pathological factors based on the lymphatic vessel system and radiological features associated with tumor with cervical neck LNM.Among patients who had undergone thyroidectomy confirmed to be papillary thyroid carcinoma, we selected 126 age-sex matched paired patients without cervical LNM (group 1) and with LNM (group 2) to evaluate risk factors.Pathological factors evaluated were size, multiplicity, and extra thyroid extension state, based on the pathological reports using stored data.The lymphatic vessel density (LVD) of each tumor was evaluated by staining for VEGFR-3 and D2-40 and correlated with cervical LNM state.Malignant ultrasound features were evaluated to compare the differences between these two groups.Larger tumor size, multiplicity, extrathyroid extension were more common in group 2 (pp value 0.040).Ultrasound (US) features had no significant differences between the two groups although calcifications tended to be higher in group 2 (84% vs. 76% p=0.264).Lymphatic vessel density and nodule echogenicity were not associated with LNM.Intratumoral lymphangiogenesis was most strongly associated with LNM and thus, could be a useful predictive marker for cervical LNM.

【 授权许可】

Unknown