Anxiolytic activity of kielmeyera rubriflora (Pau Santo) crude extract on mice

Revista Cubana de Plantas Medicinales

Becheleni Pimenta, Amine¹  Fernandes Ferreira Santos, Cynthia¹  Gregório, Luiz Elídio²  Stuckert Seixas, Sérgio Ricardo¹ 

[1] Universidade Federal dos Vales do Jequitinhonha e do Mucuri, Brasil;Universidade Federal de São Paulo, Brasil

关键词: Kielmeyera rubriflora;    anxiolytic;    sedative;    antidepressant;    CNS cerrado plants;    elevated plus maze;    hole board.;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction:the Kielmeyera rubriflora Cambess, belongs to the Clusiaceae family. It is a native plant to the Vale do Jequitinhonha in Minas Gerais in Brazil. It is used in folk medicine, however, so far there are no publications of pharmacological studies regarding this.Objective: to evaluate the anxiolytic effects of K. rubriflora extract on the central nervous system of mice.Method: the crude extract of the aerial parts was administered acutely by gavage at doses of 100 mg/kg, 250 mg/kg and 500 mg/kg in albino Swiss, males mice, between 9 and 13 weeks of age, weighing between 25 and 40 g. Spontaneous movement, potentiation of sleeping time induced by barbiturate, hole board and the elevated plus maze testes were performed.Results: the duration of sleep was not significantly altered by any of the doses of extract. The ambulation was significantly higher at doses of 100 and 500 mg/kg, suggesting an anxiolytic effect, and significantly lower at a dose of 250 mg/kg suggesting sedative effect. In the elevated plus maze test, there is less time spent in the closed arms with doses of 100mg/kg and significant increase in open arm entries with doses of 250mg/kg suggesting anxiolytic activity. In the hole board test, head dipping decrease significantly with doses of 250 mg/kg and 500 mg/kg suggesting sedative action and significant increase in head dipping with doses of 100 mg/kg suggesting anxiolytic action.Conclusion: the data suggests sedative and anxiolytic dose-dependent action of the crude extract of K.rubriflora.

【 授权许可】

CC BY-NC