Nuclear Receptor Mediated Gene Regulation through Chromatin Remodeling and Histone Modifications

Endocrine Journal

Kazuyoshi YAMAOKA¹  Ryoji FUJIKI¹  Hirochika KITAGAWA¹  Yasumasa SASAKI¹  Shinichiro TAKEZAWA¹  Shigeaki KATO¹  Masahiko KISHIMOTO¹  Takashi NAKAMURA¹ 

[1] Institute of Molecular and Cellular Biosciences, University of Tokyo

关键词: Steroidogenic acute regulatory protein (StAR);    Congenital lipoid adrenal hyperplasia;    Mutation;   

DOI  :  10.1507/endocrj.53.157

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(145)Cited-By(33)Nuclear steroid/thyroid vitamin A/D receptor genes form a gene superfamily and encode DNA-binding transcription factors that control the transcription of target genes in a ligand-dependent manner. It has become clear that chromatin remodeling and the modification of histones, the main components of chromatin, play crucial roles in gene transcription, and many distinct classes of NR-interacting co-regulators have been identified that perform significant roles in gene transcription. Since NR dysfunction can lead to the onset or progression of endocrine disease, elucidation of the mechanisms of gene regulation mediated by NRs, as well as the identification and characterization of co-regulator complexes (especially chromatin remodeling and histone-modifying complexes), is essential not only for better understanding of NR ligand function, but also for pathophysiological studies and the development of therapeutic interventions in humans.

【 授权许可】

Unknown