Leuprolide Acetate Prevents Toxic Effects of Cisplatin on The Kidneys and Gastrointestinal Tract

Endocrine Journal

KAORU NOMURA¹  TAKAO ANDO²  HIROSHI DEMURA¹ 

[1] Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College;Drug Safety Research Laboratories, Pharmaceutical Development Division, Takeda Chemical Industries, LTD

关键词: GnRH;    LH;    Renotropic activity;    Acute renal failure;    Diarrhea;   

DOI  :  10.1507/endocrj.42.315

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(20)Cited-By(2)We examined the protective effects of medical castration by means of gonadotropin-releasing hormone analogue (GnRHA) on the toxic effects of cisplatin in rats. Twelve days after a s.c. injection of a slowly-releasable form of leuprolide acetate (GnRHASR), rats were injected i.p. with cisplatin daily (3 mg/kg body weight (BW) for males and 4mg/kg BW for females) for four days and sacrificed 24h after the last injection. The doses caused acute tubular necrosis and gastrointestinal (GI) symptoms, i.e., diarrhea and fluid retention and bleeding in GI tract. GnRHASR pretreatment reduced serum urea nitrogen (SUN) and serum creatinine (SCre) increase and the incidence of GI symptoms. Histological analysis showed that rats pretreated with GnRHASR had noticeably less kidney damage. GnRHA thus demonstrated its ability to protect the kidneys and GI tract against cisplatin toxicity in both male and female rats. This finding suggests a potential clinical application of GnRHA in antineoplastic chemotherapy.

【 授权许可】

Unknown