Formaldehyde-Fixed Cells Infected with Pseudorabies Virus Conferred Resistance against Aujeszky's Disease

Journal of Veterinary Medical Science

Masashi SAKAGUCHI¹  Hajime MATSUI¹  Kazuo MATSUO¹  Michitaka YAMAMOTO¹  Takashi IMAMURA¹  Seiichi TANAKA¹ 

关键词: Aujeszky's disease;    formaldehyde-fixation;    pseudorabies virus;   

DOI  :  10.1292/jvms.56.1177

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)Cells infected with Pseudorabies virus (PrV) and fixed with formaldehyde were evaluated as a vaccine against Aujeszky's disease. Mice and pigs inoculated with fixed cells showed no clinical signs. In a challenge test, all fixed cells conferred protection on mice and pigs. Although pigs showed slight symptoms, they were restored to normal health within a few days. These results demonstrate that PrV-infected cells fixed with formaldehyde function as a vaccine against Aujeszky's disease and serve as a novel type of vaccine which is easy to make, and is both safe and effective.

【 授权许可】

Unknown