Morphometrical Analysis of Sex and Strain Differences in the Mouse Nephron

Journal of Veterinary Medical Science

Hayao Nishinakagawa¹  Akira Yabuki¹  Mitsuharu Matsumoto¹  Syusaku Suzuki² 

[1] Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University, 21-24 Korimoto 1, Kagoshima 890-0065, Japan;Institute of Laboratory Animal Science, Faculty of Medicine, Kagoshima University, 35-1 Sakuragaoka 8, Kagoshima 890-0075, Japan

关键词: kidney;    morphometry;    mouse;    sex difference;    strain difference;   

DOI  :  10.1292/jvms.61.891

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(13)Cited-By(15)In the present study, we investigated the sexual dimorphisms, effects of castration and sex hormone treatment, and strain differences in the morphology of mouse kidney by measuring the percentage of renal corpuscles with cuboidal cells in the parietal layer of the glomerular capsule, the diameter of renal corpuscles and the number of nuclei of epithelial cells in the proximal convoluted tubule. In ICR mice, the percentage of renal corpuscles with cuboidal cells and the diameter of renal corpuscles were larger in males than in females, and the numbers of nuclei were lower in males than in females. All of these parameters became similar to those of intact females by orchiectomy, and restored to levels similar to those in intact males after testosterone treatment to orchiectomized males. On the other hand, ovariectomy and estradiol treatment gave no effects to any of these parameters. Similar sexual dimorphisms were observed in BALB/c, C57BL/6, C3H/He and DBA/2 mice as in ICR mice, although the diameter of renal corpuscles was not significantly different between males and females in BALB/c mice. Strain differences were observed in each of these three parameters among the 5 strains. In conclusion, the present study demonstrated sexual dimorphisms, effects of castration and sex hormone treatment, and strain differences in the morphology of mouse kidney by morphometrical analysis.

【 授权许可】

Unknown