Bone mineral density in treated at a young age for differentiated thyroid cancer after Chernobyl female patients on TSH-suppressive therapy receiving or not Calcium-D3 supplementation

Endocrine Journal

Noboru Takamura⁵  Vladimir A. Saenko³  Tatiana A. Leonova¹  Shunichi Yamashita³  Christoph Reiners²  Mariko Mine⁶  Valentina M. Drozd⁴  Tatiana I. Rogounovitch⁵  Johannes Biko² 

[1] Counseling-diagnostic Department of thyroid diseases, Minsk City Clinical Oncologic Dispensary, Minsk 220013, Belarus;Department of Nuclear Medicine, University of Wuerzburg, Wuerzburg D-97080, Germany;Department of Health Risk Control, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan;Department of Endocrinology, Belarusian Medical Academy of Post-Graduate Education, Minsk 220013, Belarus;Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan;Biostatistics Section, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan

关键词: Bone mineral density;    Thyroid cancer;    TSH-suppressive therapy;    Calcium;    Dietary supplementation;   

DOI  :  10.1507/endocrj.EJ14-0408

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(38)Long-term management of patients with differentiated thyroid cancer (DTC) commonly includes TSH-suppressive therapy with L-T4 and, in case of postsurgical hypoparathyroidism, Calcium-D3 supplementation, both of which may affect skeletal health.Experience with female patients treated for DTC at a young age and who were then receiving long-term therapy with L-T4 and Calcium-D3 medication is very limited to date.This cross-sectional study set out to investigate effects of Calcium-D3 supplementation and TSH-suppressive therapy on bone mineral density (BMD) in 124 young female patients treated for DTC at a mean age of 14 years and followed-up for an average of 10 years.BMD was found to be significantly higher in patients receiving Calcium-D3 medication than in patients not taking supplements.The level of ionized calcium was the strongest factor determining lumbar spine BMD in patients not receiving Calcium-D3 supplementation.Pregnancy ending in childbirth and HDL-cholesterol were associated with a weak adverse effect on spine and femoral BMD.No evidence of adverse effects of L-T4 and of radioiodine therapies on BMD was found.We conclude that Calcium-D3 medication has a beneficial effect on BMD, and that TSH-suppressive therapy does not affect BMD in women treated for DTC at young age, at least after 10 years of follow-up.

【 授权许可】

Unknown