New Frontiers in Gut Nutrient Sensor Research: Nutrient Sensors in the Gastrointestinal Tract: Modulation of Sweet Taste Sensitivity by Leptin

Journal of Pharmacological Sciences

Yuzo Ninomiya¹  Noriatsu Shigemura¹  Masafumi Jyotaki¹  Ryusuke Yoshida¹  Nao Horio¹  Keisuke Sanematsu¹ 

[1] Section of Oral Neuroscience, Kyushu University, Graduate School of Dental Sciences, Japan

关键词: sweet taste;    leptin;    modulation;    energy homeostasis;    gastrointestinal tract;   

DOI  :  10.1254/jphs.09R07FM

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(28)Cited-By(10)The ability to perceive sweet compounds is important for animals to detect an external carbohydrate source of calories and has a critical role in the nutritional status of animals. In mice, a subset of sweet-sensitive taste cells possesses leptin receptors. Increase of plasma leptin with increasing internal energy storage in the adipose tissue suppresses sweet taste responses via this receptor. The data from recent studies indicate that leptin may also act as a modulator of sweet taste sensation in humans with a diurnal variation in sweet sensitivity. The plasma leptin level and sweet taste sensitivity are proposed to link with post-ingestive plasma glucose level. This leptin modulation of sweet taste sensitivity may influence an individual’s preference, ingestive behavior, and absorption of nutrients, thereby playing important roles in regulation of energy homeostasis.

【 授权许可】

Unknown