Journal of Pharmacological Sciences | |
Swallowing Disorder and Inhibition of Cough Reflex Induced by Atropine Sulfate in Conscious Dogs | |
Shinichi Sugimoto1  Takaki Seki1  Shinji Tsujimoto1  Yasunori Katsura1  Tadashi Tsubouchi1  Terumasa Mino1  | |
[1] Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., Japan | |
关键词: swallowing disorder; inhibition of cough reflex; anti-cholinergic agent; dog; aspiration pneumonia; | |
DOI : 10.1254/jphs.FP0071553 | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(34)Cited-By(1)In this study, the effects of atropine sulfate (atropine) on swallowing and cough reflex were evaluated in the two experimental models in conscious dogs. To evaluate the effects of atropine on swallowing, 1 mL of marker (contrast medium) was injected into the pharynx under X-ray exposure to induce swallowing. Baclofen, used as a positive control, caused marker congestion in the upper esophagus. In our experimental model, atropine (0.02 and 0.1 mg/kg, i.v.) dose-dependently increased not only the number of marker congestions but also that of the swallows. In addition, atropine significantly shortened the onset of first swallowing. In the evaluation of atropine effects on electrically evoked cough reflex induced by two electrodes implanted into the trachea, atropine strongly inhibited the number of coughs at 0.01 or 0.05 mg/kg accompanied with 0.01 or 0.05 mg/kg per hour (i.v.), respectively. These findings indicate that atropine has the potential of causing aspiration pneumonia through induction of swallowing disorder and inhibition of the cough reflex.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201911300728035ZK.pdf | 551KB | download |