Swallowing Disorder and Inhibition of Cough Reflex Induced by Atropine Sulfate in Conscious Dogs

Journal of Pharmacological Sciences

Shinichi Sugimoto¹  Takaki Seki¹  Shinji Tsujimoto¹  Yasunori Katsura¹  Tadashi Tsubouchi¹  Terumasa Mino¹ 

[1] Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., Japan

关键词: swallowing disorder;    inhibition of cough reflex;    anti-cholinergic agent;    dog;    aspiration pneumonia;   

DOI  :  10.1254/jphs.FP0071553

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(34)Cited-By(1)In this study, the effects of atropine sulfate (atropine) on swallowing and cough reflex were evaluated in the two experimental models in conscious dogs. To evaluate the effects of atropine on swallowing, 1 mL of marker (contrast medium) was injected into the pharynx under X-ray exposure to induce swallowing. Baclofen, used as a positive control, caused marker congestion in the upper esophagus. In our experimental model, atropine (0.02 and 0.1 mg/kg, i.v.) dose-dependently increased not only the number of marker congestions but also that of the swallows. In addition, atropine significantly shortened the onset of first swallowing. In the evaluation of atropine effects on electrically evoked cough reflex induced by two electrodes implanted into the trachea, atropine strongly inhibited the number of coughs at 0.01 or 0.05 mg/kg accompanied with 0.01 or 0.05 mg/kg per hour (i.v.), respectively. These findings indicate that atropine has the potential of causing aspiration pneumonia through induction of swallowing disorder and inhibition of the cough reflex.

【 授权许可】

Unknown