Journal of Veterinary Medical Science | |
Genetic and Pathobiological Characterization of Bovine Viral Diarrhea Viruses Recently Isolated from Cattle in Japan | |
Asako ITO1  Hiroshi KIDA1  Ken-ichiro KAMEYAMA1  Yoshihiro SAKODA1  Keita MATSUNO1  Kyuzo TAMAI1  | |
[1] Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University | |
关键词: bovine viral diarrhea virus; molecular epidemiology; pathogenicity; phylogenetic analysis; | |
DOI : 10.1292/jvms.69.515 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(43)Cited-By(13)The 475 strains of bovine viral diarrhea virus (BVDV) isolated from cattle in 12 prefectures of Japan in the last 7 years were phylogenetically classified as BVDV-1 or BVDV-2 on the basis of the nucleotide sequence of the 5'-untranslated region. BVDV-1 strains were further subtyped as 1a (101 strains), 1b (163), 1c (128), 1j (3), and So CP/75-like (1), and all of the 79 BVDV-2 strains belonged to subtype 2a. These 2a BVDVs contain two isolates that had high nucleotide identities with those of highly pathogenic BVDV-2 strains reported in North America (Pellerin et al., 1994). However, acute infection with severe mortality like North American outbreak was not observed and most of the present BVDV-2 strains were isolated from persistently infected (PI) cattle showing mild or no clinical sign. Moreover, it was revealed that 61.5% of the 39 PI cattle with cytopathogenic BVDVs did not show typical mucosal disease and 54.6% of the 405 PI animals only with non-cytopathogenic BVDVs were apparently healthy. The present results indicate that the prevention of the infection with an appropriate vaccine and active surveillance covering healthy cattle are required for the control of BVD.
【 授权许可】
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