Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls

Endocrine Journal

Dan Jiang²  Wenjun Sun²  Chaoming Mao²  Weiyun Qian¹  Libin Zhou³  Xiafei Hong²  Hao Hu²  Dong Wang²  Ruirong Pan²  Yuanxin Liu²  Qichao Yang²  Shuqin Yu²  Haoying Xue²  Guoyue Yuan²  Su Wang² 

[1] Department of Endocrinology, the Third Affiliated Hospital of Suchow University, Changzhou 213000, China;Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China;Ruijin Hospital, Center of Molecular Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Jiaotong University Medical School, Shanghai 200025, China

关键词: Fibroblast growth factor 1;    Newly diagnosed;    Type 2 diabetes;   

DOI  :  10.1507/endocrj.EJ15-0627

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(29)Cited-By(1)Fibroblast growth factor 1 (FGF1) has been recently characterized as a potent insulin sensitizer that regulates adipose tissue remodeling, but the physiological role of FGF1 remains unclear.This study measured serum FGF1 levels for the first time in patients with newly diagnosed type 2 diabetes mellitus (T2DM), and further explored the correlations between FGF1 levels and various metabolic parameters in T2DM.Serum FGF1 levels were determined using ELISA in age-, sex- and BMI- matched subjects with normal glucose tolerance (NGT) (n=80) and newly diagnosed T2DM (n=80).Oral glucose tolerance test (OGTT), glycosylated hemoglobin (HbA1C), blood lipids, and insulin secretion were also measured.Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of beta cell function (HOMA-β), respectively.Serum FGF1 levels were significantly higher in T2DM patients than in normal glucose tolerance subjects (74.52 [55.91∼101.34] vs. 60.31 [48.99∼83.91] pg/mL; P<0.05).In addition, serum FGF1 level positively correlated with body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), fasting plasma glucose (FPG), 2-h post-OGTT glucose (2h PG), and HbA1C (all P values <0.05) in T2DM subjects.Multivariate regression analyses showed that BMI and HbA1C were the independent factors influencing serum FGF1 levels.Logistic regression analyses demonstrated that serum FGF1 was significantly associated with type 2 diabetes (P<0.01).Circulating concentrations of FGF1 are significantly increased in T2DM patients.Our results suggest that FGF1 may play a role in the pathogenesis of T2DM.

【 授权许可】

Unknown