The Immediate Early Gene of Canine Herpesvirus is Transcribed through Early and Late Phases

Journal of Veterinary Medical Science

Hiroshi KIDA¹  Mitsuyoshi TAKIGUCHI²  Masahiro MIYOSHI²  Akira HASHIMOTO²  Katsunori OKAZAKI¹ 

[1] Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University;Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University

关键词: CHV;    IE gene;    transcription;   

DOI  :  10.1292/jvms.64.627

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(28)The immediate early (IE) gene of canine herpesvirus (CHV), homologue of the infected cell protein 4 (ICP4) gene of herpes simplex virus 1, is transcribed as a 4.9kb mRNA during IE phase. The IE gene was further transcribed as a 4.8kb mRNA through early (E) and late (L) phases of productive infection. Transcription of the 4.8kb mRNA initiated from downstream of the TATA box in an intron which was spliced out during IE phase. The reverse transcription-polymerase chain reaction revealed that the IE promoter was turned off during L phase at a permissive temperature. We, thus, propose to redesignate the IE gene of CHV as CICP4 gene.

【 授权许可】

Unknown