First description of an olfactory neuroblastoma in goldfish Carassius auratus: a case report

Diseases of Aquatic Organisms

R. Bermúdez¹  M. I. Quiroga¹  A. J. Marcaccini¹  F. A. Vigliano¹  J. Sarradell¹ 

关键词: Tumour;    Olfactory neuroblastoma;    Goldfish;    Carassius auratus;    Histopathology;    Immunohistochemistry;   

DOI  :  10.3354/dao02383

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: An external pinkish growing mass that emerged from the right nostril of an adult goldfish Carassius auratus L. was evaluated by means of light microscopy and immunohistochemistry. The neoplasm presented a well-developed fibrovascular stroma associated with solid cell nests and a large number of Flexner-Wintersteiner rosettes. Myelinated fibres were observed around them. Neoplastic cells showed a prominent degree of nuclear atypia and low mitotic activity. The latter was in agreement with the low reactivity of tumour cells to anti-proliferating cell nuclear antigen antibody. Immunohistochemistry also revealed anti-neuronal nitric oxide synthase, anti-S100 protein, anti-­neuropeptide Y, and anti-cytokeratin immunoreactivity in tumour cells as well as in normal olfactory epithelium of goldfish control sections. Histopathological and immunohistochemical findings strongly suggest a diagnosis of an olfactory neuroblastoma (ONB). To our knowledge this is the first description of ONB in goldfish.

【 授权许可】

Unknown