Effects of SA13353, a Transient Receptor Potential Vanilloid 1 Agonist, on Leukocyte Infiltration in Lipopolysaccharide-Induced Acute Lung Injury and Ovalbumin-Induced Allergic Airway Inflammation

Journal of Pharmacological Sciences

Hiroyuki Inoue¹  Fumio Tsuji¹  Hiroyuki Aono¹  Minoru Sasano¹  Kenji Oki¹  Hiroyuki Tanaka²  Masaaki Murai¹  Naoki Inagaki² 

[1] Research and Development Center, Santen Pharmaceutical Co., Ltd., Japan;Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

关键词: SA13353;    transient receptor potential vanilloid 1;    lung inflammation;   

DOI  :  10.1254/jphs.09295SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(10)We recently demonstrated that SA13353, a transient receptor potential vanilloid 1 (TRPV1) agonist, reduced the severity of the symptoms of kidney injury, arthritis, and encephalomyelitis in disease models. Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation. In LPS-induced lung injury, SA13353 attenuated neutrophil infiltration and the increase of TNF-α and CINC-1 levels. In allergic airway inflammation, SA13353 tended to inhibit leukocyte infiltration and attenuated the increase of IL-4 and IL-12p40. These results suggest that somatosensory TRPV1 may play an anti-inflammatory role in lung inflammation.

【 授权许可】

Unknown