Mouse Lethal Activity of a HEp-2 Vacuolation Factor, Cereulide, Produced by Bacillus cereus Isolated from Vomiting-Type Food Poisoning

Journal of Veterinary Medical Science

Dongliang HU¹  Shigeko UEDA¹  Yasuteru UENO¹  Shunji SUGII¹  Kunihiro SHINAGAWA¹ 

关键词: Bacillus cereus;    emesis;    suncus;   

DOI  :  10.1292/jvms.58.10_1027

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)Cited-By(16)The HEp-2 vacuolation factor (or cereulide) produced by Bacillus cereus isolated from vomiting-type food poisoning, which is supposed to induce emesis, was found to give mouse and suncus lethality after intravenous and intraperitoneal administration. The emetic activity of the factor was also found to be resistant to heating at 121°C for 15 min, exposure to pH 2 and 11, and to digestion with proteolytic enzymes such as pepsin and trypsin. These findings suggest that the cereulide produced by B. cereus is stable in the digestive tracts, induce emesis, and show lethal activity leading to cellular damage.

【 授权许可】

Unknown