Transcatheter Arterial Embolization for the Treatment of Liver Metastases in a Patient with Malignant Pheochromocytoma

Endocrine Journal

Mika TSUIKI²  Kazue TAKANO²  Nobuyuki TORII¹  Daisuke WATANABE²  Akiyo TANABE²  Mitsuhide NARUSE³  Takao NOSHIRO⁴ 

[1] Department of Medicine, Institute of Clinical Gastroenterology, Tokyo Women's Medical University;Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University;Division of Endocrinology, Clinical Research Institute of Endocrine and Metabolic Diseases, Kyoto Medical Center;Noshiro Clinic

关键词: Malignant pheochromocytoma;    Multiple hepatic tumors;    Transcatheter arterial embolization (TAE);    Chromogranin A;   

DOI  :  10.1507/endocrj.53.59

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(24)Cited-By(8)A 63-year-old male patient was admitted for the treatment of malignant pheochromocytoma with multiple liver metastases. Plasma and urinary levels of catecholamines were elevated. Transcatheter arterial embolization (TAE) with concomitant administration of mitomycin C and gelatin sponge was performed for the treatment of liver metastases. Dose of alpha-1 blocker before TAE was increased to prevent hypertensive crisis during and after TAE. The hepatic metastatic lesion of CT findings was decreased after TAE. Although blood pressure showed a transient hypertension (180/100 mmHg) after every TAE, it returned rapidly to normal. The patient experienced transient abdominal pain, nausea, and loss of appetite after every TAE; however, those symptoms were readily controlled by conventional medications. Slight elevation of liver transaminases was recognized but returned to normal range within 3 weeks. No other major side effects were seen with TAE. While plasma and urinary level of catecholamines were unchanged, plasma chromogranin A (CgA) level was significantly decreased. These results suggest that TAE is a useful treatment for hepatic metastases. Plasma CgA level is a useful marker in the treatment of malignant pheochromocytoma.

【 授权许可】

Unknown