Acute Hyperglycemia and Activation of the β-Adrenergic System do not Exhibit Synergistic Inhibitory Actions on Thyrotropin-releasing Hormone (TRH)-induced Thyroid Stimulating Hormone (TSH) Secretion

Endocrine Journal

Kiwon OH¹  Seungjoon OH²  Sungwoo PARK¹  Eunhee KIM³  Gwanpyo KOH²  Youngseol KIM²  Seungjoon PARK³  Cheolyoung PARK¹  Inmyung YANG²  Sookjin SOHN³  Sungwoon KIM²  Jeongtaek WOO²  Jinwoo KIM² 

[1] Department of Internal Medicine, College of Medicine, Hallym University, Hallym Sacred Heart Hospital;Department of Internal Medicine, Kyunghee University School of Medicine;Department of Pharmacology and Medical Science and Engineering Research Center for Reactive Oxygen Species, Kyunghee University School of Medicine

关键词: Hyperglycemia;    Isoproterenol;    Thyrotropin-Releasing Hormone (TRH);    Thyroid Stimulating Hormone (TSH);   

DOI  :  10.1507/endocrj.52.69

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(32)Cited-By(1)Thyrotropin-releasing hormone (TRH)-stimulated thyroid stimulating hormone (TSH) response in normal subjects is suppressed by oral glucose administration. Pharmacologic studies indicate that this suppressive action of glucose is mediated by an increase in hypothalamic somatostatin (SRIH) tone. Since activation of the β-adrenergic system also suppresses basal TSH secretion by enhancing SRIH release we sought to determine whether isoproterenol alters the suppression of TRH-induced TSH response induced by the stimulation of glucose. Four tests were performed in seven healthy young men: Test 1: 200 μg TRH (iv) at 0 min; Test 2: 100 g oral glucose at –30 min and TRH at 0 min; Test 3: TRH at 0 min with isoproterenol (0.012 μg/kg, iv) infused continuously; Test 4: oral glucose at –30 min, TRH at 0 min with isoproterenol infused continuously. Pretreatment with glucose significantly suppressed TRH-induced TSH secretion. Isoproterenol infusion also suppressed the TRH-induced TSH secretion, but it did not enhance the inhibitory action of glucose on TSH secretion. The degree of suppression induced by glucose was significantly higher than that achieved by isoproterenol. These data suggest that combined administration of glucose and isoproterenol does not exhibit synergistic inhibitory actions on TRH-stimulated TSH secretion, and that the glucose-TRH test could be used for the evaluation of the hypothalamic somatostatinergic activity.

【 授权许可】

Unknown