N-of-1 trials of quinine efficacy in skeletal muscle cramps of the leg

British Journal of General Practice

Felicity Goodyear-Smith¹  Bruce Arroll¹  Rachel Woodfield¹ 

[1] School of Pharmacy, University of Otago, Dunedin, New Zealand

关键词: muscle cramp;    placebos;    quinine;    randomized controlled trials;   

DOI  :  

学科分类：卫生学

来源: Royal College of General Practitioners

【 摘 要 】

Skeletal muscle cramps affect over a third of the ambulatory elderly population. Quinine is the established treatment, but there are safety concerns, and evidence for efficacy is conflicting. A recent meta-analysis established a small advantage for quinine, but identified the need for additional studies. N-of-1 trials compare two treatments, in a randomised, double-blind, multiple crossover study on a patient-by-patient basis. They have been used to compare treatments in osteoarthritis and may be suitable for determining the individual efficacy of quinine.

【 授权许可】

Unknown