Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study

Brazilian Journal of Infectious Diseases

Amaral, Rose Luce do⁴  Gonçalves, Ana Katherine da Silveira¹  Eleutério Júnior, José²  Silva, Maria José Penna Maisonnette de Attayde⁵  Gabiatti, José Roberto Erbolato³  Florêncio, Gilzandra Lira Dantas⁵ 

[1]UFRN, Brazil

[2]Universidade Federal do Ceará, Brazil

[3]Universidade Estadual de Campinas, Brazil

[4]UNICAMP

[5]Universidade Federal do Rio Grande do Norte

关键词: Chlamydia trachomatis;    perinatal mortality;    morbidity;    meta-analysis;   

DOI  :  10.1590/S1413-86702011000600006

来源: Contexto

【 摘 要 】

OBJECTIVE: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality.METHODS: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis.RESULTS: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively).CONCLUSION: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings.

【 授权许可】

CC BY-NC-ND