Oligodendroglial Vacuolar Degeneration in the Bilateral Motor Cortices and Astrocytosis in Epileptic Beagle Dogs

Journal of Veterinary Medical Science

Takeshi UMEMURA²  Satoshi FUKUDA³  Akinori SHIMADA¹  Takehito MORITA¹  Eisaku OHAMA⁴ 

[1] Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan;Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan;Division of Radiotoxicology and Protection, National Institute of Radiological Sciences, Inageku, Chiba 263-0024, Japan;Division of Neuropathology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago 683-0826, Japan

关键词: canine;    epilepsy;    gliosis;    oligodendrocyte;   

DOI  :  10.1292/jvms.61.107

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(2)We performed a pathologic examination of the brains of three dogs in an epileptic beagle colony. Histologically, all the cases had diffuse astrocytosis in the cerebral cortex and basal ganglia as well as the hippocampus, whereas they showed acute nerve cell change in the hippocampus and some other areas of the cerebrum. One of these animals showed laminar myelin pallor associated with the presence of many vacuoles in the IV to VI layers of the bilateral motor cortices. Most of the vacuoles contained fine granules stained with luxol-fast-blue stain. Ultrastructural examination revealed that some oligodendrocytes and perineuronal satellite oligodendrocytes in the bilateral cerebral motor cortices of the two affected dogs had many vacuoles surrounded by myelin-like lamellar structures. These findings suggest a possibility that astrocytosis in the cerebrum and vacuolar degeneration of oligodendrocytes in the cerebral motor cortex may be, at least in part, related to the occurrence or development of seizures.

【 授权许可】

Unknown