High Rates of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and Human Immunodeficiency Virus Infections and Uncommon HBV Genotype/Subtype and HCV Subtype Distributions among Transgender Individuals in Surabaya, Indonesia

Japanese Journal of Infectious Diseases

Rury Mega Wahyuni²  Soetjipto³  Mochamad Amin²  Alfonsus Adrian Hadikusumo³  Takako Utsumi²  Edhi Rianto³  Maria Inge Lusida³  Siti Qamariyah Khairunisa²  Yoshitake Hayashi¹  Juniastuti³  Anittaqwa Istimagfirah² 

[1] Center for Infectious Diseases, Kobe University Graduate School of Medicine;Indonesia-Japan Collaborative Research Centre for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University;Faculty of Medicine, Airlangga University

关键词: hepatitis B virus;    hepatitis C virus;    human immunodeficiency virus;    Indonesia;    transgender;   

DOI  :  10.7883/yoken.JJID.2015.384

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(47)Transgender people are at a high risk for sexually transmitted viruses such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Moreover, Indonesia has a moderate-to-high rate of HBV infection and rapid epidemic growth of HIV infection; hepatitis C virus (HCV) infection can co-occur with HBV and HIV infections. In this study, 10 of 107 individuals (9.3%) were positive for HBV surface antigen (HBsAg) and/or HBV DNA, whereas 19 of 101 individuals (18.8%) with negative results for HBsAg were positive for HBV core antibody (anti-HBc). Seven of the 107 individuals (6.5%) were anti-HCV positive, and 16 of the 100 tested samples (16.0%) were HIV positive. Genotype and subtype analyses of all 10 HBV DNA (6 HBsAg positive and 4 anti-HBc positive) strains showed that 3 were of the HBV genotype/HBsAg subtype C/adrq+, one was of C/adw2, and 5 were of B/adw2. The HCV subtype distribution showed that 33.3% were of HCV-1b, and 66.7% were of HCV-3k (n = 6). These distributions differed from those found in the general population of Surabaya, Indonesia. Interestingly, HIV subtype analysis showed a high prevalence of HIV, with possible recombinants of CRF01_AE and subtype B.

【 授权许可】

Unknown